PLA2G7 genotype, Lp-PLA2 activity and coronary heart disease risk in 10,494 cases and 15,624 controls of European ancestry

BACKGROUND: Higher Lp-PLA2 activity is associated with increased risk of coronary heart disease (CHD), making Lp-PLA2 a potential therapeutic target. PLA2G7 variants associated with Lp-PLA2 activity could evaluate whether this relationship is causal. METHODS AND RESULTS: A meta-analysis including a...

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Detalhes bibliográficos
Main Authors: Casas, Juan P., Ninio, Ewa, Panayiotou, Andrie, Palmen, Jutta, Cooper, Jackie A, Ricketts, Sally L, Sofat, Reecha, Nicolaides, Andrew N, Corsetti, James P, Fowkes, F Gerry R, Tzoulaki, Ioanna, Kumari, Meena, Brunner, Eric J, Kivimaki, Mika, Marmot, Michael G, Hoffmann, Michael M, Winkler, Karl, März, Winfred, Ye, Shu, Stirnadel, Heide A, MBBChir, Kay-Tee Khaw, Humphries, Steve E, Sandhu, Manjinder S, Hingorani, Aroon D, Talmud, Philippa J
Formato: Artigo
Idioma:Inglês
Publicado em: 2010
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Article
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC3377948/
https://ncbi.nlm.nih.gov/pubmed/20479152
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1161/CIRCULATIONAHA.109.923383
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