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Runx1 dose-dependently regulates endochondral ossification during skeletal development and fracture healing
Runx1 is expressed in skeletal elements, but its role in fracture repair has not been analyzed. We created mice with a hypomorphic Runx1 allele (Runx1(L148A)) and generated Runx1(L148A/−) mice in which >50% of Runx1 activity was abrogated. Runx1(L148A/−) mice were viable but runted. Their growth...
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| Main Authors: | , , , , , , , |
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| Format: | Artigo |
| Sprog: | Inglês |
| Udgivet: |
2012
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| Fag: | |
| Online adgang: | https://ncbi.nlm.nih.gov/pmc/articles/PMC3377839/ https://ncbi.nlm.nih.gov/pubmed/22431360 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1002/jbmr.1601 |
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