Age-Related Intraneuronal Elevation of αII-Spectrin Breakdown Product SBDP120 in Rodent Forebrain Accelerates in 3×Tg-AD Mice

Spectrins line the intracellular surface of plasmalemma and play a critical role in supporting cytoskeletal stability and flexibility. Spectrins can be proteolytically degraded by calpains and caspases, yielding breakdown products (SBDPs) of various molecular sizes, with SBDP120 being largely derive...

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Bibliographische Detailangaben
Hauptverfasser: Cai, Yan, Zhu, Hai-Xia, Li, Jian-Ming, Luo, Xue-Gang, Patrylo, Peter R., Rose, Gregory M., Streeter, Jackson, Hayes, Ron, Wang, Kevin K. W., Yan, Xiao-Xin, Jeromin, Andreas
Format: Artigo
Sprache:Inglês
Veröffentlicht: Public Library of Science 2012
Schlagworte:
Research Article
Online Zugang:https://ncbi.nlm.nih.gov/pmc/articles/PMC3377681/
https://ncbi.nlm.nih.gov/pubmed/22723836
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1371/journal.pone.0037599
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