Paradoxical Lower Serum Triglyceride Levels and Higher Type 2 Diabetes Mellitus Susceptibility in Obese Individuals with the PNPLA3 148M Variant

BACKGROUND: Obesity is highly associated with elevated serum triglycerides, hepatic steatosis and type 2 diabetes (T2D). The I148M (rs738409) genetic variant of patatin-like phospholipase domain-containing 3 gene (PNPLA3) is known to modulate hepatic triglyceride accumulation, leading to steatosis....

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Αποθηκεύτηκε σε:
Λεπτομέρειες βιβλιογραφικής εγγραφής
Κύριοι συγγραφείς: Palmer, Colin N. A., Maglio, Cristina, Pirazzi, Carlo, Burza, Maria Antonella, Adiels, Martin, Burch, Lindsay, Donnelly, Louise A., Colhoun, Helen, Doney, Alexander S., Dillon, John F., Pearson, Ewan R., McCarthy, Mark, Hattersley, Andrew T., Frayling, Tim, Morris, Andrew D., Peltonen, Markku, Svensson, Per-Arne, Jacobson, Peter, Borén, Jan, Sjöström, Lars, Carlsson, Lena M. S., Romeo, Stefano
Μορφή: Artigo
Γλώσσα:Inglês
Έκδοση: Public Library of Science 2012
Θέματα:
Research Article
Διαθέσιμο Online:https://ncbi.nlm.nih.gov/pmc/articles/PMC3377675/
https://ncbi.nlm.nih.gov/pubmed/22724004
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1371/journal.pone.0039362
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