PNPLA 3 I148M genetic variant associates with insulin resistance and baseline viral load in HCV genotype 2 but not in genotype 3 infection

BACKGROUND: Hepatic steatosis in HCV patients has been postulated as a risk factor associated with a higher frequency of fibrosis and cirrhosis. A single genetic variant, PNPLA3 I148M, has been widely associated with increased hepatic steatosis. Previous studies of the PNPLA3 I148M sequence variant...

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Autori principali: Rembeck, Karolina, Maglio, Cristina, Lagging, Martin, Christensen, Peer Brehm, Färkkilä, Martti, Langeland, Nina, Buhl, Mads Rauning, Pedersen, Court, Mørch, Kristine, Norkrans, Gunnar, Hellstrand, Kristoffer, Lindh, Magnus, Pirazzi, Carlo, Burza, Maria Antonella, Romeo, Stefano, Westin, Johan
Natura: Artigo
Lingua:Inglês
Pubblicazione: BioMed Central 2012
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Research Article
Accesso online:https://ncbi.nlm.nih.gov/pmc/articles/PMC3495049/
https://ncbi.nlm.nih.gov/pubmed/22978414
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1186/1471-2350-13-82
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