Detection of Crosslinks within and between Proteins by LC-MALDI-TOFTOF and the Software FINDX to Reduce the MSMS-Data to Acquire for Validation

Lysine-specific chemical crosslinking in combination with mass spectrometry is emerging as a tool for the structural characterization of protein complexes and protein-protein interactions. After tryptic digestion of crosslinked proteins there are thousands of peptides amenable to MSMS, of which only...

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Detalhes bibliográficos
Main Authors: Söderberg, Christopher A. G., Lambert, Wietske, Kjellström, Sven, Wiegandt, Alena, Wulff, Ragna Peterson, Månsson, Cecilia, Rutsdottir, Gudrun, Emanuelsson, Cecilia
Formato: Artigo
Idioma:Inglês
Publicado em: Public Library of Science 2012
Assuntos:
Research Article
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC3377668/
https://ncbi.nlm.nih.gov/pubmed/22723907
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1371/journal.pone.0038927
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