Sodium Phenylbutyrate Controls Neuroinflammatory and Antioxidant Activities and Protects Dopaminergic Neurons in Mouse Models of Parkinson’s Disease

Neuroinflammation and oxidative stress underlie the pathogenesis of various neurodegenerative disorders. Here we demonstrate that sodium phenylbutyrate (NaPB), an FDA-approved therapy for reducing plasma ammonia and glutamine in urea cycle disorders, can suppress both proinflammatory molecules and r...

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Bibliographische Detailangaben
Hauptverfasser: Roy, Avik, Ghosh, Anamitra, Jana, Arundhati, Liu, Xiaojuan, Brahmachari, Saurav, Gendelman, Howard E., Pahan, Kalipada
Format: Artigo
Sprache:Inglês
Veröffentlicht: Public Library of Science 2012
Schlagworte:
Research Article
Online Zugang:https://ncbi.nlm.nih.gov/pmc/articles/PMC3377667/
https://ncbi.nlm.nih.gov/pubmed/22723850
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1371/journal.pone.0038113
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