Sodium Phenylbutyrate Controls Neuroinflammatory and Antioxidant Activities and Protects Dopaminergic Neurons in Mouse Models of Parkinson’s Disease

Neuroinflammation and oxidative stress underlie the pathogenesis of various neurodegenerative disorders. Here we demonstrate that sodium phenylbutyrate (NaPB), an FDA-approved therapy for reducing plasma ammonia and glutamine in urea cycle disorders, can suppress both proinflammatory molecules and r...

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Detalhes bibliográficos
Main Authors: Roy, Avik, Ghosh, Anamitra, Jana, Arundhati, Liu, Xiaojuan, Brahmachari, Saurav, Gendelman, Howard E., Pahan, Kalipada
Formato: Artigo
Idioma:Inglês
Publicado em: Public Library of Science 2012
Assuntos:
Research Article
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC3377667/
https://ncbi.nlm.nih.gov/pubmed/22723850
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1371/journal.pone.0038113
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