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Oncogene addiction as a foundational rationale for targeted anti-cancer therapy: promises and perils
A decade has elapsed since the concept of oncogene addiction was first proposed. It postulates that – despite the diverse array of genetic lesions typical of cancer – some tumours rely on one single dominant oncogene for growth and survival, so that inhibition of this specific oncogene is sufficient...
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| Main Authors: | , |
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| Formato: | Artigo |
| Idioma: | Inglês |
| Publicado em: |
WILEY-VCH Verlag
2011
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| Assuntos: | |
| Acesso em linha: | https://ncbi.nlm.nih.gov/pmc/articles/PMC3377106/ https://ncbi.nlm.nih.gov/pubmed/21953712 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1002/emmm.201100176 |
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