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FIST, a sword and shield fusokine for cancer immunotherapy
To antagonize tumor-derived TGFβ contemporaneously to anticancer immunotherapy, we genetically engineered a fusion protein coupling IL-2 and the ectodomain of TGFβ receptor II (Fusion of Interleukin-2 and Soluble TGFβ receptor – a.k.a. FIST). FIST possesses intriguing gain-of-function properties and...
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| Main Authors: | , |
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| Formato: | Artigo |
| Idioma: | Inglês |
| Publicado em: |
Landes Bioscience
2012
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| Assuntos: | |
| Acesso em linha: | https://ncbi.nlm.nih.gov/pmc/articles/PMC3376982/ https://ncbi.nlm.nih.gov/pubmed/22720250 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.4161/onci.1.2.18458 |
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