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Dysregulation of anti-tumor immunity by the matrix metalloproteinase-2
The matrix metalloproteinase-2 (MMP-2), overexpressed in most cancers, induces TH2 polarization by conditioning dendritic cells to over-express OX40L and downregulate IL-12p70 through the degradation of the type-I IFN receptor IFNAR1. Elucidating mechanisms underlying detrimental tumor-associated ty...
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| Auteurs principaux: | , |
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| Format: | Artigo |
| Langue: | Inglês |
| Publié: |
Landes Bioscience
2012
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| Sujets: | |
| Accès en ligne: | https://ncbi.nlm.nih.gov/pmc/articles/PMC3376966/ https://ncbi.nlm.nih.gov/pubmed/22720227 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.4161/onci.1.1.17994 |
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