Tumour growth inhibition and anti-metastatic activity of a mutated furin-resistant Semaphorin 3E isoform

Secreted Semaphorin 3E (Sema3E) promotes cancer cell invasiveness and metastatic spreading. The pro-metastatic activity of Sema3E is due to its proteolytic fragment p61, capable of transactivating the oncogenic tyrosine kinase ErbB2 that associates with the Sema3E receptor PlexinD1 in cancer cells....

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Bibliographic Details
Main Authors: Casazza, Andrea, Kigel, Boaz, Maione, Federica, Capparuccia, Lorena, Kessler, Ofra, Giraudo, Enrico, Mazzone, Massimiliano, Neufeld, Gera, Tamagnone, Luca
Format: Artigo
Language:Inglês
Published: WILEY-VCH Verlag 2012
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Research Article
Online Access:https://ncbi.nlm.nih.gov/pmc/articles/PMC3376853/
https://ncbi.nlm.nih.gov/pubmed/22247010
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1002/emmm.201100205
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