TRPC3 and TRPC6 are essential for normal mechanotransduction in subsets of sensory neurons and cochlear hair cells

Transient receptor potential (TRP) channels TRPC3 and TRPC6 are expressed in both sensory neurons and cochlear hair cells. Deletion of TRPC3 or TRPC6 in mice caused no behavioural phenotype, although loss of TRPC3 caused a shift of rapidly adapting (RA) mechanosensitive currents to intermediate-adap...

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Main Authors: Quick, Kathryn, Zhao, Jing, Eijkelkamp, Niels, Linley, John E., Rugiero, Francois, Cox, James J., Raouf, Ramin, Gringhuis, Martine, Sexton, Jane E., Abramowitz, Joel, Taylor, Ruth, Forge, Andy, Ashmore, Jonathan, Kirkwood, Nerissa, Kros, Corné J., Richardson, Guy P., Freichel, Marc, Flockerzi, Veit, Birnbaumer, Lutz, Wood, John N.
Formato: Artigo
Idioma:Inglês
Publicado: The Royal Society 2012
Assuntos:
Research
Acceso en liña:https://ncbi.nlm.nih.gov/pmc/articles/PMC3376737/
https://ncbi.nlm.nih.gov/pubmed/22724068
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1098/rsob.120068
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