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p53 mediated senescence impairs the apoptotic response to chemotherapy and clinical outcome in breast cancer
Studies on the role of TP53 mutation in breast cancer response to chemotherapy are conflicting. Here, we show that, contrary to dogma, MMTV-Wnt1 mammary tumors with mutant p53 exhibited a superior clinical response compared to tumors with wild-type p53. Doxorubicin-treated p53-mutant tumors failed t...
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| Main Authors: | , , , , , , , , , , , |
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| Formato: | Artigo |
| Idioma: | Inglês |
| Publicado em: |
2012
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| Assuntos: | |
| Acesso em linha: | https://ncbi.nlm.nih.gov/pmc/articles/PMC3376352/ https://ncbi.nlm.nih.gov/pubmed/22698404 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.ccr.2012.04.027 |
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