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Withaferin A Alters Intermediate Filament Organization, Cell Shape and Behavior

Withaferin A (WFA) is a steroidal lactone present in Withania somnifera which has been shown in vitro to bind to the intermediate filament protein, vimentin. Based upon its affinity for vimentin, it has been proposed that WFA can be used as an anti-tumor agent to target metastatic cells which up-reg...

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Main Authors: Grin, Boris, Mahammad, Saleemulla, Wedig, Tatjana, Cleland, Megan M., Tsai, Lester, Herrmann, Harald, Goldman, Robert D.
格式: Artigo
語言:Inglês
出版: Public Library of Science 2012
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在線閱讀:https://ncbi.nlm.nih.gov/pmc/articles/PMC3376126/
https://ncbi.nlm.nih.gov/pubmed/22720028
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1371/journal.pone.0039065
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