Development of Novel Single-Stranded Nucleic Acid Aptamers against the Pro-Angiogenic and Metastatic Enzyme Heparanase (HPSE1)

Heparanase is an enzyme involved in extracellular matrix remodelling and heparan sulphate proteoglycan catabolism. It is secreted by metastatic tumour cells, allowing them to penetrate the endothelial cell layer and basement membrane to invade target organs. The release of growth factors at the site...

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Detalhes bibliográficos
Main Authors: Simmons, Suzanne C., McKenzie, Edward A., Harris, Lynda K., Aplin, John D., Brenchley, Paul E., Velasco-Garcia, Maria N., Missailidis, Sotiris
Formato: Artigo
Idioma:Inglês
Publicado em: Public Library of Science 2012
Assuntos:
Research Article
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC3376095/
https://ncbi.nlm.nih.gov/pubmed/22719856
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1371/journal.pone.0037938
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