Bcl10 Links Saturated Fat Overnutrition with Hepatocellular NF-κB Activation and Insulin Resistance

Excess serum free fatty acids (FFAs) are fundamental to the pathogenesis of insulin resistance. With high fat feeding, FFAs activate NF-κB in target tissues, initiating negative cross-talk with insulin signaling. However, the mechanisms underlying FFA-dependent NF-κB activation remain unclear. Here...

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Detalhes bibliográficos
Main Authors: Van Beek, Matthew, Oravecz-Wilson, Katherine I., Delekta, Phillip C., Gu, Shufang, Li, Xiangquan, Jin, Xiaohong, Apel, Ingrid J., Konkle, Katy S., Feng, Yongjia, Teitelbaum, Daniel H., Ruland, Jürgen, McAllister-Lucas, Linda M., Lucas, Peter C.
Formato: Artigo
Idioma:Inglês
Publicado em: 2012
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Article
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC3375919/
https://ncbi.nlm.nih.gov/pubmed/22708078
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.celrep.2012.04.006
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