Alpha- and beta-secretase activity as a function of age and beta-amyloid in Down syndrome and normal brain

Aged individuals with Down syndrome (DS) develop Alzheimer's disease (AD) neuropathology by the age of 40 years. The purpose of the current study was to measure age-associated changes in APP processing in 36 individuals with DS (5 months–69 years) and in 26 controls (5 months–100 years). Alpha-...

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Main Authors: Nistor, M., Don, M., Parekh, M., Sarsoza, F., Goodus, M., Lopez, G.E., Kawas, C., Leverenz, J., Doran, E., Lott, I.T., Hill, M., Head, E.
Format: Artigo
Language:Inglês
Published: 2006
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Article
Online Access:https://ncbi.nlm.nih.gov/pmc/articles/PMC3375834/
https://ncbi.nlm.nih.gov/pubmed/16904243
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.neurobiolaging.2006.06.023
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