Glutamate Transporter Studies Reveal the Pruning of Metabotropic Glutamate Receptors and Absence of AMPA Receptor Desensitization at Mature Calyx of Held Synapses

We examined the effect of glutamate transporter blockade at the calyx of Held synapse. In immature synapses [defined as postnatal day 8 (P8) to P10 rats], transporter blockade causes tonic activation of NMDA receptors and strong inhibition of the AMPA receptor-mediated EPSC amplitude. EPSC inhibitio...

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Main Authors: Renden, Robert, Taschenberger, Holger, Puente, Nagore, Rusakov, Dmitri A., Duvoisin, Robert, Wang, Lu-Yang, Lehre, Knut P., von Gersdorff, Henrique
Formato: Artigo
Idioma:Inglês
Publicado: Society for Neuroscience 2005
Assuntos:
Cellular/Molecular
Acceso en liña:https://ncbi.nlm.nih.gov/pmc/articles/PMC3375655/
https://ncbi.nlm.nih.gov/pubmed/16162930
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1523/JNEUROSCI.1848-05.2005
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