Targeted Overexpression of Inducible 6-Phosphofructo-2-kinase in Adipose Tissue Increases Fat Deposition but Protects against Diet-induced Insulin Resistance and Inflammatory Responses

Increasing evidence demonstrates the dissociation of fat deposition, the inflammatory response, and insulin resistance in the development of obesity-related metabolic diseases. As a regulatory enzyme of glycolysis, inducible 6-phosphofructo-2-kinase (iPFK2, encoded by PFKFB3) protects against diet-i...

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Detalhes bibliográficos
Main Authors: Huo, Yuqing, Guo, Xin, Li, Honggui, Xu, Hang, Halim, Vera, Zhang, Weiyu, Wang, Huan, Fan, Yang-Yi, Ong, Kuok Teong, Woo, Shih-Lung, Chapkin, Robert S., Mashek, Douglas G., Chen, Yanming, Dong, Hui, Lu, Fuer, Wei, Lai, Wu, Chaodong
Formato: Artigo
Idioma:Inglês
Publicado em: American Society for Biochemistry and Molecular Biology 2012
Assuntos:
Metabolism
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC3375570/
https://ncbi.nlm.nih.gov/pubmed/22556414
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1074/jbc.M112.370379
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