Astrocytes Secrete Exosomes Enriched with Proapoptotic Ceramide and Prostate Apoptosis Response 4 (PAR-4): POTENTIAL MECHANISM OF APOPTOSIS INDUCTION IN ALZHEIMER DISEASE (AD)

Amyloid protein is well known to induce neuronal cell death, whereas only little is known about its effect on astrocytes. We found that amyloid peptides activated caspase 3 and induced apoptosis in primary cultured astrocytes, which was prevented by caspase 3 inhibition. Apoptosis was also prevented...

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Bibliographische Detailangaben
Hauptverfasser: Wang, Guanghu, Dinkins, Michael, He, Qian, Zhu, Gu, Poirier, Christophe, Campbell, Andrew, Mayer-Proschel, Margot, Bieberich, Erhard
Format: Artigo
Sprache:Inglês
Veröffentlicht: American Society for Biochemistry and Molecular Biology 2012
Schlagworte:
Neurobiology
Online Zugang:https://ncbi.nlm.nih.gov/pmc/articles/PMC3375560/
https://ncbi.nlm.nih.gov/pubmed/22532571
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1074/jbc.M112.340513
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