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Specific Soluble Oligomers of Amyloid-β Peptide Undergo Replication and Form Non-fibrillar Aggregates in Interfacial Environments

Aggregates of amyloid-β (Aβ) peptides have been implicated in the etiology of Alzheimer disease. Among the different forms of Aβ aggregates, low molecular weight species ranging between ∼2- and 50-mers, also called “soluble oligomers,” have emerged as the species responsible for early synaptic dysfu...

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Bibliographische Detailangaben
Hauptverfasser: Kumar, Amit, Paslay, Lea C., Lyons, Daniel, Morgan, Sarah E., Correia, John J., Rangachari, Vijayaraghavan
Format: Artigo
Sprache:Inglês
Veröffentlicht: American Society for Biochemistry and Molecular Biology 2012
Schlagworte:
Online Zugang:https://ncbi.nlm.nih.gov/pmc/articles/PMC3375547/
https://ncbi.nlm.nih.gov/pubmed/22544746
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1074/jbc.M112.355156
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