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Partitioning-defective Protein 6 (Par-6) Activates Atypical Protein Kinase C (aPKC) by Pseudosubstrate Displacement

Atypical protein kinase C (aPKC) controls cell polarity by modulating substrate cortical localization. Aberrant aPKC activity disrupts polarity, yet the mechanisms that control aPKC remain poorly understood. We used a reconstituted system with purified components and a cultured cell cortical displac...

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Hlavní autoři: Graybill, Chiharu, Wee, Brett, Atwood, Scott X., Prehoda, Kenneth E.
Médium: Artigo
Jazyk:Inglês
Vydáno: American Society for Biochemistry and Molecular Biology 2012
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On-line přístup:https://ncbi.nlm.nih.gov/pmc/articles/PMC3375524/
https://ncbi.nlm.nih.gov/pubmed/22544755
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1074/jbc.M112.360495
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