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Rab5 Proteins Regulate Activation and Localization of Target of Rapamycin Complex 1

The mechanistic target of rapamycin (mTOR) complex 1 is regulated by small GTPase activators and localization signals. We examine here the role of the small GTPase Rab5 in the localization and activation of TORC1 in yeast and mammalian cells. Rab5 mutants disrupt mTORC1 activation and localization i...

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Detalhes bibliográficos
Main Authors: Bridges, Dave, Fisher, Kaleigh, Zolov, Sergey N., Xiong, Tingting, Inoki, Ken, Weisman, Lois S., Saltiel, Alan R.
Formato: Artigo
Idioma:Inglês
Publicado em: American Society for Biochemistry and Molecular Biology 2012
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Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC3375515/
https://ncbi.nlm.nih.gov/pubmed/22547071
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1074/jbc.M111.334060
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