Glycine insertion at protease cleavage site of SNAP25 resists cleavage but enhances affinity for botulinum neurotoxin serotype A

The light chain of botulinum neurotoxin A (BoNT/A-LC) is a Zn-dependent protease that specifically cleaves SNAP25 of the SNARE complex, thereby impairing vesicle fusion and neurotransmitter release at neuromuscular junctions. The C-terminus of SNAP25 (residues 141–206) retains full activity for BoNT...

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Main Authors: Ho, Mengfei, Goh, Cheong-Hian, Brothers, Michael C, Wang, Shihua, Young, Ryan L, Ou, Yuxiang, Lui, Juliana Nga-Man, Kalafatis, Marinos, Lan, Xiuwan, Wolf, Abigail E, Rienstra, Chad M, Wilson, Brenda A
Format: Artigo
Sprog:Inglês
Udgivet: Wiley Subscription Services, Inc., A Wiley Company 2012
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Articles
Online adgang:https://ncbi.nlm.nih.gov/pmc/articles/PMC3375433/
https://ncbi.nlm.nih.gov/pubmed/22170566
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1002/pro.2017
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