Genetic Polymorphisms of the Human PNPLA3 Gene Are Strongly Associated with Severity of Non-Alcoholic Fatty Liver Disease in Japanese

BACKGROUND: Nonalcoholic fatty liver disease (NAFLD) includes a broad range of liver pathologies from simple steatosis to cirrhosis and fibrosis, in which a subtype accompanying hepatocyte degeneration and fibrosis is classified as nonalcoholic steatohepatitis (NASH). NASH accounts for approximately...

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Autori principali: Kawaguchi, Takahisa, Sumida, Yoshio, Umemura, Atsushi, Matsuo, Keitaro, Takahashi, Meiko, Takamura, Toshinari, Yasui, Kohichiroh, Saibara, Toshiji, Hashimoto, Etsuko, Kawanaka, Miwa, Watanabe, Sumio, Kawata, Sumio, Imai, Yasuharu, Kokubo, Miki, Shima, Toshihide, Park, Hyohun, Tanaka, Hideo, Tajima, Kazuo, Yamada, Ryo, Matsuda, Fumihiko
Natura: Artigo
Lingua:Inglês
Pubblicazione: Public Library of Science 2012
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Research Article
Accesso online:https://ncbi.nlm.nih.gov/pmc/articles/PMC3375283/
https://ncbi.nlm.nih.gov/pubmed/22719876
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1371/journal.pone.0038322
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