Genotoxicity of the cancer chemopreventive drug candidates CP-31398, SHetA2, and phospho-ibuprofen

The genotoxic activities of three cancer chemopreventive drug candidates, CP-31398 (a cell permeable styrylquinazoline p53 modulator, SHetA2 (a flexible heteroarotinoid), and phospho-ibuprofen (PI, a derivative of ibuprofen) were tested. None of the compounds were mutagenic in the Salmonella/Escheri...

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Autori principali: Doppalapudi, Rupa S., Riccio, Edward S., Davis, Zoe, Menda, Sean, Wang, Abraham, Du, Nicholas, Green, Carol, Kopelovich, Levy, Rao, Chinthalapally V., Benbrook, Doris M., Kapetanovic, Izet M.
Natura: Artigo
Lingua:Inglês
Pubblicazione: 2012
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Accesso online:https://ncbi.nlm.nih.gov/pmc/articles/PMC3375211/
https://ncbi.nlm.nih.gov/pubmed/22498038
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.mrgentox.2012.03.009
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