A Single E627K Mutation in the PB2 Protein of H9N2 Avian Influenza Virus Increases Virulence by Inducing Higher Glucocorticoids (GCs) Level

While repeated infection of humans and enhanced replication and transmission in mice has attracted more attention to it, the pathogenesis of H9N2 virus was less known in mice. PB(2) residue 627 as the virulent determinant of H5N1 virus is associated with systemic infection and impaired TCR activatio...

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Bibliografiske detaljer
Main Authors: Tian, Jin, Qi, Wenbao, Li, Xiaokang, He, Jun, Jiao, Peirong, Zhang, Changhui, Liu, Guo-Qian, Liao, Ming
Format: Artigo
Sprog:Inglês
Udgivet: Public Library of Science 2012
Fag:
Research Article
Online adgang:https://ncbi.nlm.nih.gov/pmc/articles/PMC3374829/
https://ncbi.nlm.nih.gov/pubmed/22719870
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1371/journal.pone.0038233
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