Esterified eicosanoids are acutely generated by 5-lipoxygenase in primary human neutrophils and in human and murine infection

5-Lipoxygenase (5-LOX) plays key roles in infection and allergic responses. Herein, four 5-LOX–derived lipids comprising 5-hydroxyeicosatetraenoic acid (HETE) attached to phospholipids (PLs), either phosphatidylethanolamine (PE) or phosphatidylcholine (18:0p/5-HETE-PE, 18:1p/5-HETE-PE, 16:0p/5-HETE-...

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Hauptverfasser: Clark, Stephen R., Guy, Christopher J., Scurr, Martin J., Taylor, Philip R, Kift-Morgan, Ann P., Hammond, Victoria J., Thomas, Christopher P., Coles, Barbara, Roberts, Gareth W., Eberl, Matthias, Jones, Simon A., Topley, Nicholas, Kotecha, Sailesh, O'Donnell, Valerie B.
Format: Artigo
Sprache:Inglês
Veröffentlicht: American Society of Hematology 2011
Schlagworte:
Phagocytes, Granulocytes, and Myelopoiesis
Online Zugang:https://ncbi.nlm.nih.gov/pmc/articles/PMC3374621/
https://ncbi.nlm.nih.gov/pubmed/21177434
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1182/blood-2010-04-278887
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