A High-Throughput Scintillation Proximity-Based Assay for Human DNA Ligase IV

Ionizing radiation (IR) and certain chemotherapeutic drugs are designed to generate cytotoxic DNA double-strand breaks (DSBs) in cancer cells. Inhibition of the major DSB repair pathway, nonhomologous end joining (NHEJ), will enhance the cytotoxicity of these agents. Screening for inhibitors of the...

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Главные авторы: Tseng, Hui-Min, Shum, David, Bhinder, Bhavneet, Escobar, Sindy, Veomett, Nicholas J., Tomkinson, Alan E., Gin, David Y., Djaballah, Hakim, Scheinberg, David A.
Формат: Artigo
Язык:Inglês
Опубликовано: Mary Ann Liebert, Inc. 2012
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Original Articles
Online-ссылка:https://ncbi.nlm.nih.gov/pmc/articles/PMC3374410/
https://ncbi.nlm.nih.gov/pubmed/22192310
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1089/adt.2011.0404
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