Adaptive Auto-Regulation of Androgen Receptor Provides a Paradigm Shifting Rationale for Bipolar Androgen Therapy (BAT) for Castrate Resistant Human Prostate Cancer

Cell culture/xenograft and gene arrays of clinical material document that development of castration resistant prostate cancer (CRPC) cells involves acquisition of adaptive auto-regulation resulting in > 25 fold increase in Androgen Receptor (AR) protein expression in a low androgen environment. S...

Ausführliche Beschreibung

Gespeichert in:
Bibliographische Detailangaben
Hauptverfasser: Isaacs, John T., D’Antonio, Jason M., Chen, Shuangling, Antony, Lizamma, Dalrymple, Susan P., Ndikuyeze, Georges H., Luo, Jun, Denmeade, Samuel R.
Format: Artigo
Sprache:Inglês
Veröffentlicht: 2012
Schlagworte:
Article
Online Zugang:https://ncbi.nlm.nih.gov/pmc/articles/PMC3374010/
https://ncbi.nlm.nih.gov/pubmed/22396319
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1002/pros.22504
Tags: Tag hinzufügen
Keine Tags, Fügen Sie den ersten Tag hinzu!

Ähnliche Einträge