Adaptive Auto-Regulation of Androgen Receptor Provides a Paradigm Shifting Rationale for Bipolar Androgen Therapy (BAT) for Castrate Resistant Human Prostate Cancer

Cell culture/xenograft and gene arrays of clinical material document that development of castration resistant prostate cancer (CRPC) cells involves acquisition of adaptive auto-regulation resulting in > 25 fold increase in Androgen Receptor (AR) protein expression in a low androgen environment. S...

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Main Authors: Isaacs, John T., D’Antonio, Jason M., Chen, Shuangling, Antony, Lizamma, Dalrymple, Susan P., Ndikuyeze, Georges H., Luo, Jun, Denmeade, Samuel R.
Format: Artigo
Jezik:Inglês
Izdano: 2012
Teme:
Article
Online dostop:https://ncbi.nlm.nih.gov/pmc/articles/PMC3374010/
https://ncbi.nlm.nih.gov/pubmed/22396319
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1002/pros.22504
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