Aberrant substrate engagement of the ER translocon triggers degradation by the Hrd1 ubiquitin ligase

Little is known about quality control of proteins that aberrantly or persistently engage the endoplasmic reticulum (ER)-localized translocon en route to membrane localization or the secretory pathway. Hrd1 and Doa10, the primary ubiquitin ligases that function in ER-associated degradation (ERAD) in...

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Bibliographic Details
Main Authors: Rubenstein, Eric M., Kreft, Stefan G., Greenblatt, Wesley, Swanson, Robert, Hochstrasser, Mark
Format: Artigo
Language:Inglês
Published: The Rockefeller University Press 2012
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Research Articles
Online Access:https://ncbi.nlm.nih.gov/pmc/articles/PMC3373407/
https://ncbi.nlm.nih.gov/pubmed/22689655
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1083/jcb.201203061
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