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The IFT-A complex regulates Shh signaling through cilia structure and membrane protein trafficking
Two intraflagellar transport (IFT) complexes, IFT-A and IFT-B, build and maintain primary cilia and are required for activity of the Sonic hedgehog (Shh) pathway. A weak allele of the IFT-A gene, Ift144, caused subtle defects in cilia structure and ectopic activation of the Shh pathway. In contrast,...
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| 主要な著者: | , , , , , , , |
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| フォーマット: | Artigo |
| 言語: | Inglês |
| 出版事項: |
The Rockefeller University Press
2012
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| 主題: | |
| オンライン･アクセス: | https://ncbi.nlm.nih.gov/pmc/articles/PMC3373400/ https://ncbi.nlm.nih.gov/pubmed/22689656 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1083/jcb.201110049 |
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