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Canalization of the evolutionary trajectory of the human influenza virus

BACKGROUND: Since its emergence in 1968, influenza A (H3N2) has evolved extensively in genotype and antigenic phenotype. However, despite strong pressure to evolve away from human immunity and to diversify in antigenic phenotype, H3N2 influenza shows paradoxically limited genetic and antigenic diver...

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Bibliografiske detaljer
Main Authors: Bedford, Trevor, Rambaut, Andrew, Pascual, Mercedes
Format: Artigo
Sprog:Inglês
Udgivet: BioMed Central 2012
Fag:
Online adgang:https://ncbi.nlm.nih.gov/pmc/articles/PMC3373370/
https://ncbi.nlm.nih.gov/pubmed/22546494
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1186/1741-7007-10-38
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