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Canalization of the evolutionary trajectory of the human influenza virus

BACKGROUND: Since its emergence in 1968, influenza A (H3N2) has evolved extensively in genotype and antigenic phenotype. However, despite strong pressure to evolve away from human immunity and to diversify in antigenic phenotype, H3N2 influenza shows paradoxically limited genetic and antigenic diver...

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Autors principals: Bedford, Trevor, Rambaut, Andrew, Pascual, Mercedes
Format: Artigo
Idioma:Inglês
Publicat: BioMed Central 2012
Matèries:
Accés en línia:https://ncbi.nlm.nih.gov/pmc/articles/PMC3373370/
https://ncbi.nlm.nih.gov/pubmed/22546494
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1186/1741-7007-10-38
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