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Structural origins of high apparent dielectric constants experienced by ionizable groups in the hydrophobic core of a protein
The side chains of Lys-66, Asp-66, and Glu-66 in staphylococcal nuclease (SNase) are fully buried and surrounded mainly by hydrophobic matter, save for internal water molecules associated with carboxylic oxygen atoms. These ionizable side chains titrate with pK(a) values of 5.7, 8.8 and 8.9, respect...
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| Autors principals: | , , , |
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| Format: | Artigo |
| Idioma: | Inglês |
| Publicat: |
2010
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| Matèries: | |
| Accés en línia: | https://ncbi.nlm.nih.gov/pmc/articles/PMC3373013/ https://ncbi.nlm.nih.gov/pubmed/21059359 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.jmb.2010.10.001 |
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