Antibody Pressure by a Human Monoclonal Antibody Targeting the 2009 Pandemic H1N1 Virus Hemagglutinin Drives the Emergence of a Virus with Increased Virulence in Mice

In 2009, a novel H1N1 influenza A virus (2009 pH1N1) emerged and caused a pandemic. A human monoclonal antibody (hMAb; EM4C04), highly specific for the 2009 pH1N1 virus hemagglutinin (HA), was isolated from a severely ill 2009 pH1N1 virus-infected patient. We postulated that under immune pressure wi...

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Bibliographic Details
Main Authors: O’Donnell, Christopher D., Vogel, Leatrice, Wright, Amber, Das, Suman R., Wrammert, Jens, Li, Gui-Mei, McCausland, Megan, Zheng, Nai-Ying, Yewdell, Jonathan W., Ahmed, Rafi, Wilson, Patrick C., Subbarao, Kanta
Format: Artigo
Language:Inglês
Published: American Society of Microbiology 2012
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Research Article
Online Access:https://ncbi.nlm.nih.gov/pmc/articles/PMC3372962/
https://ncbi.nlm.nih.gov/pubmed/22647789
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1128/mBio.00120-12
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