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Antibody Pressure by a Human Monoclonal Antibody Targeting the 2009 Pandemic H1N1 Virus Hemagglutinin Drives the Emergence of a Virus with Increased Virulence in Mice
In 2009, a novel H1N1 influenza A virus (2009 pH1N1) emerged and caused a pandemic. A human monoclonal antibody (hMAb; EM4C04), highly specific for the 2009 pH1N1 virus hemagglutinin (HA), was isolated from a severely ill 2009 pH1N1 virus-infected patient. We postulated that under immune pressure wi...
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| Prif Awduron: | , , , , , , , , , , , |
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| Fformat: | Artigo |
| Iaith: | Inglês |
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American Society of Microbiology
2012
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| Mynediad Ar-lein: | https://ncbi.nlm.nih.gov/pmc/articles/PMC3372962/ https://ncbi.nlm.nih.gov/pubmed/22647789 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1128/mBio.00120-12 |
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