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Systemic VHL gene functions and the VHL disease

The von Hippel-Lindau tumor suppressor gene (VHL) is best known as an E3 ubiquitin ligase that negatively regulates the hypoxia inducible factor (HIF). VHL mutations are the genetic defects underlying several human diseases including polycythemia, familial VHL tumor syndrome and sporadic renal cell...

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Bibliografiske detaljer
Main Authors: Bader, Hannah L., Hsu, Tien
Format: Artigo
Sprog:Inglês
Udgivet: 2012
Fag:
Online adgang:https://ncbi.nlm.nih.gov/pmc/articles/PMC3372859/
https://ncbi.nlm.nih.gov/pubmed/22673568
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.febslet.2012.04.032
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