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Systemic VHL gene functions and the VHL disease
The von Hippel-Lindau tumor suppressor gene (VHL) is best known as an E3 ubiquitin ligase that negatively regulates the hypoxia inducible factor (HIF). VHL mutations are the genetic defects underlying several human diseases including polycythemia, familial VHL tumor syndrome and sporadic renal cell...
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| Format: | Artigo |
| Sprache: | Inglês |
| Veröffentlicht: |
2012
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| Schlagworte: | |
| Online Zugang: | https://ncbi.nlm.nih.gov/pmc/articles/PMC3372859/ https://ncbi.nlm.nih.gov/pubmed/22673568 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.febslet.2012.04.032 |
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