Roflumilast inhibits the release of chemokines and TNF-α from human lung macrophages stimulated with lipopolysaccharide

BACKGROUND AND PURPOSE: Lung macrophages are critically involved in respiratory diseases. This study assessed the effects of the PDE4 inhibitor roflumilast and its active metabolite, roflumilast N-oxide on the release of a range of chemokines (CCL2, 3, 4, CXCL1, 8, 10) and of TNF-α, from human lung...

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Main Authors: Buenestado, A, Grassin-Delyle, S, Guitard, F, Naline, E, Faisy, C, Israël-Biet, D, Sage, E, Bellamy, JF, Tenor, H, Devillier, P
Formato: Artigo
Idioma:Inglês
Publicado: Blackwell Publishing Ltd 2012
Assuntos:
Research Papers
Acceso en liña:https://ncbi.nlm.nih.gov/pmc/articles/PMC3372837/
https://ncbi.nlm.nih.gov/pubmed/21913898
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1111/j.1476-5381.2011.01667.x
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