Clinical Relevance of the Anti-inflammatory Effects of Roflumilast on Human Bronchus: Potentiation by a Long-Acting Beta-2-Agonist

Background: Roflumilast is an option for treating patients with severe COPD and frequent exacerbations despite optimal therapy with inhaled drugs. The present study focused on whether the phosphodiesterase (PDE) 4 inhibitor roflumilast and its active metabolite roflumilast N-oxide affect the release...

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Detalhes bibliográficos
Publicado no:Front Pharmacol
Main Authors: Salvator, Hélène, Buenestado, Amparo, Brollo, Marion, Naline, Emmanuel, Victoni, Tatiana, Longchamp, Elisabeth, Tenor, Hermann, Grassin-Delyle, Stanislas, Devillier, Philippe
Formato: Artigo
Idioma:Inglês
Publicado em: Frontiers Media S.A. 2020
Assuntos:
Pharmacology
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC7754640/
https://ncbi.nlm.nih.gov/pubmed/33363471
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.3389/fphar.2020.598702
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