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Inhibitory effect of bufalin and cinobufagin on steroidogenesis via the activation of ERK in human adrenocortical cells

BACKGROUND AND PURPOSE: Bufalin and cinobufagin exhibit cardiotonic and natriuretic activities. The aim of this study was to evaluate the effects of bufalin and cinobufagin on aldosterone and cortisol secretion and their mechanisms of action in human adrenocortical cells (NCI-H295). EXPERIMENTAL APP...

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Hlavní autoři: Kau, Mei-Mei, Wang, Jiing-Rong, Tsai, Shiow-Chwen, Yu, Ching-Han, Wang, Paulus S
Médium: Artigo
Jazyk:Inglês
Vydáno: Blackwell Publishing Ltd 2012
Témata:
On-line přístup:https://ncbi.nlm.nih.gov/pmc/articles/PMC3372836/
https://ncbi.nlm.nih.gov/pubmed/21913902
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1111/j.1476-5381.2011.01671.x
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