Clozapine, but not haloperidol, enhances glial d-serine and L-glutamate release in rat frontal cortex and primary cultured astrocytes

BACKGROUND AND PURPOSE: Deficient transmission at the glutamate NMDA receptor is considered a key component of the pathophysiology of schizophrenia. However, the effects of antipsychotic drugs on the release of the endogenous NMDA receptor partial agonist, d-serine, remain to be clarified. EXPERIMEN...

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Hlavní autoři: Tanahashi, Shunske, Yamamura, Satoshi, Nakagawa, Masanori, Motomura, Eishi, Okada, Motohiro
Médium: Artigo
Jazyk:Inglês
Vydáno: Blackwell Publishing Ltd 2012
Témata:
Research Papers
On-line přístup:https://ncbi.nlm.nih.gov/pmc/articles/PMC3372736/
https://ncbi.nlm.nih.gov/pubmed/21880034
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1111/j.1476-5381.2011.01638.x
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