Inhibition of T-type calcium current in rat thalamocortical neurons by isoflurane

Thalamocortical (TC) neurons provide the major sensory input to the mammalian somatosensory cortex. Decreased activity of these cells may be pivotal in the ability of general anesthetics to induce loss of consciousness and promote sleep (hypnosis). T-type voltage-gated calcium currents (T-currents)...

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Hauptverfasser: Eckle, Veit-Simon, DiGruccio, Michael R., Uebele, Victor N., Renger, John J., Todorovic, Slobodan M.
Format: Artigo
Sprache:Inglês
Veröffentlicht: 2012
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Article
Online Zugang:https://ncbi.nlm.nih.gov/pmc/articles/PMC3372673/
https://ncbi.nlm.nih.gov/pubmed/22491022
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.neuropharm.2012.03.018
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