MAVS ubiquitination by the E3 ligase TRIM25 and degradation by the proteasome is involved in type I interferon production after activation of the antiviral RIG-I-like receptors

BACKGROUND: During a viral infection, the intracellular RIG-I-like receptors (RLRs) sense viral RNA and signal through the mitochondrial antiviral signaling adaptor MAVS (also known as IPS-1, Cardif and VISA) whose activation triggers a rapid production of type I interferons (IFN) and of pro-inflamm...

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Bibliographic Details
Main Authors: Castanier, Céline, Zemirli, Naima, Portier, Alain, Garcin, Dominique, Bidère, Nicolas, Vazquez, Aimé, Arnoult, Damien
Format: Artigo
Language:Inglês
Published: BioMed Central 2012
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Research Article
Online Access:https://ncbi.nlm.nih.gov/pmc/articles/PMC3372421/
https://ncbi.nlm.nih.gov/pubmed/22626058
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1186/1741-7007-10-44
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