Large-scale experimental studies show unexpected amino acid effects on protein expression and solubility in vivo in E. coli

The biochemical and physical factors controlling protein expression level and solubility in vivo remain incompletely characterized. To gain insight into the primary sequence features influencing these outcomes, we performed statistical analyses of results from the high-throughput protein-production...

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Bibliographic Details
Main Authors: Price, W Nicholson, Handelman, Samuel K, Everett, John K, Tong, Saichiu N, Bracic, Ana, Luff, Jon D, Naumov, Victor, Acton, Thomas, Manor, Philip, Xiao, Rong, Rost, Burkhard, Montelione, Gaetano T, Hunt, John F
Format: Artigo
Language:Inglês
Published: BioMed Central 2011
Subjects:
Research
Online Access:https://ncbi.nlm.nih.gov/pmc/articles/PMC3372292/
https://ncbi.nlm.nih.gov/pubmed/22587847
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1186/2042-5783-1-6
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