Deep Intron Elements Mediate Nested Splicing Events at Consecutive AG Dinucleotides To Regulate Alternative 3′ Splice Site Choice in Vertebrate 4.1 Genes

Distal intraexon (iE) regulatory elements in 4.1R pre-mRNA govern 3′ splice site choice at exon 2 (E2) via nested splicing events, ultimately modulating expression of N-terminal isoforms of cytoskeletal 4.1R protein. Here we explored intrasplicing in other normal and disease gene contexts and found...

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Main Authors: Parra, Marilyn K., Gallagher, Thomas L., Amacher, Sharon L., Mohandas, Narla, Conboy, John G.
Formato: Artigo
Idioma:Inglês
Publicado: American Society for Microbiology 2012
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Articles
Acceso en liña:https://ncbi.nlm.nih.gov/pmc/articles/PMC3372232/
https://ncbi.nlm.nih.gov/pubmed/22473990
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1128/MCB.05716-11
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