Reconstruction of Human Papillomavirus Type 16-Mediated Early-Stage Neoplasia Implicates E6/E7 Deregulation and the Loss of Contact Inhibition in Neoplastic Progression

Infection with human papillomavirus type 16 (HPV-16) can lead to low- or high-grade squamous intraepithelial lesions (LSIL or HSIL). Here we show that these in vivo disease states can be replicated in raft cultures of early-pass HPV-16 episomal cell lines, at both the level of pathology and the leve...

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Autors principals: Isaacson Wechsler, Erin, Wang, Qian, Roberts, Ian, Pagliarulo, Emilio, Jackson, Deborah, Untersperger, Christina, Coleman, Nick, Griffin, Heather, Doorbar, John
Format: Artigo
Idioma:Inglês
Publicat: American Society for Microbiology 2012
Matèries:
Pathogenesis and Immunity
Accés en línia:https://ncbi.nlm.nih.gov/pmc/articles/PMC3372204/
https://ncbi.nlm.nih.gov/pubmed/22457518
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1128/JVI.07069-11
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