Foamy Virus Pol Protein Expressed as a Gag-Pol Fusion Retains Enzymatic Activities, Allowing for Infectious Virus Production

Foamy viruses (FV) synthesize Pol from a spliced pol mRNA independently of Gag, unlike orthoretroviruses, which synthesize Pol as a Gag-Pol protein that coassembles with Gag. We found that prototype FV (PFV) mutants expressing Gag and Pol only as a Gag-Pol protein without the spliced Pol contain pro...

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Detaylı Bibliyografya
Asıl Yazarlar: Lee, Eun-Gyung, Sinicrope, Amber, Jackson, Dana L., Yu, Shuyuarn F., Linial, Maxine L.
Materyal Türü: Artigo
Dil:Inglês
Baskı/Yayın Bilgisi: American Society for Microbiology 2012
Konular:
Genome Replication and Regulation of Viral Gene Expression
Online Erişim:https://ncbi.nlm.nih.gov/pmc/articles/PMC3372200/
https://ncbi.nlm.nih.gov/pubmed/22491447
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1128/JVI.06979-11
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