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Large-scale screening of yeast mutants for sensitivity to the IMP dehydrogenase inhibitor 6-azauracil

Mutations in several genes encoding components of the RNA polymerase II elongation machinery render S. cerevisiae cells sensitive to the drug 6-azauracil (6AU), an inhibitor of IMP dehydrogenase and orotidylate decarboxylase. It is thought that a reduction in nucleotide levels following drug treatme...

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Main Authors: Riles, Linda, Shaw, Randal J., Johnston, Mark, Reines, Daniel
Formato: Artigo
Idioma:Inglês
Publicado: 2004
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Acceso en liña:https://ncbi.nlm.nih.gov/pmc/articles/PMC3371602/
https://ncbi.nlm.nih.gov/pubmed/14968429
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1002/yea.1068
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