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Functional Distinctions between IMP Dehydrogenase Genes in Providing Mycophenolate Resistance and Guanine Prototrophy to Yeast()

IMP dehydrogenase (IMPDH) catalyzes the rate-limiting step in the de novo synthesis of GTP. Yeast with mutations in the transcription elongation machinery are sensitive to inhibitors of this enzyme such as 6-azauracil and mycophenolic acid, at least partly because of their inability to transcription...

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Detaylı Bibliyografya
Asıl Yazarlar: Hyle, Judith W., Shaw, Randal J., Reines, Daniel
Materyal Türü: Artigo
Dil:Inglês
Baskı/Yayın Bilgisi: 2003
Konular:
Online Erişim:https://ncbi.nlm.nih.gov/pmc/articles/PMC3367515/
https://ncbi.nlm.nih.gov/pubmed/12746440
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1074/jbc.M303736200
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